Public Health
Neurotech Pharmaceuticals, Inc. announced that the Company"s product candidate, NT-501, demonstrated a strong biologic effect in two Phase 2 clinical trials for retinitis pigmentosa (RP). RP is a slowly developing condition that causes the progressive degeneration of rod & cone photoreceptor cells in the retina that over time diminishes night and peripheral vision and eventually leads to blindness. RP is an orphan-designated indication for which there are currently no approved treatments.
Results and additional analyses from the Phase II portion of a Phase II/III clinical trial of Corthera"s investigational drug relaxin for the treatment of acute heart failure will be presented at the Heart Failure Congress, the annual meeting of the Heart Failure Association of the European Society of Cardiology in Nice, France.
President Obama is "right to push for [health care] reform now, despite calls to postpone efforts solely on the economic recovery," a Philadelphia Inquirer editorial states. According to the editorial, cost-cutting initiatives proposed by industry groups earlier this week "may not amount to anything" because they are voluntary and "providers" past efforts at containing costs have failed every time." However, the groups" vow to reduce future health care spending by $2 trillion "shows how much fat and waste is in the system," according to the Inquirer. The editorial also states that the "most assured means of tamping down costs while providing greater access to health coverage could be through" a government-run public health insurance option. In addition, Obama "needs to warm to the idea of requiring that all Americans obtain health insurance," in order to spread out the cost of care, the editorial continues. The editorial concludes that "it"s encouraging that Obama doesn"t plan to let a couple of wars and a recession sidetrack him from his pledge to reform health care and expand coverage to all Americans" (Philadelphia Inquirer, 5/14). Opinion Piece
An experimental drug derived from cottonseed shows promise in treating the recurrence of glioblastoma multiforme, widely considered the most lethal brain cancer, said researchers at the University of Alabama at Birmingham (UAB).
After roughly a month of emergency response to the new H1N1 swine flu virus, US health authorities are taking stock, re-focusing and re-
In research that could open new avenues of treatment for seasonal allergies, a team of Yale University scientists has discovered how a poorly understood component of the human immune system triggers - and sometimes worsens - allergic reactions. The research appears in the May 24 Advance Online Publication of Nature Immunology.
The average U.S. family and their employers paid an additional $1,017 in health care premiums in 2008 to pay for care of the uninsured, according to a study released on Thursday by Families USA, USA Today reports (Kim, USA Today, 5/28). According to the study, which examined federal data, the uninsured received $116 billion in health care from hospitals, physicians and other providers in 2008 and paid 37% of that amount. Government programs and charities covered an additional 26%, which left another 37%, or about $43 billion, unpaid. The study then estimated how those costs are when spread across the insured through higher premiums, the study found. According to the study, prepared by the actuarial firm Milliman, the average additional amount paid under private coverage for single individuals was about $370 per year (Werner, AP/Austin American-Statesman, 5/28). Families USA Executive Director Ron Pollack said, "This is a hidden tax on all insurance premiums, whether it is paid by business for their work or by families when they purchase their own coverage" (USA Today, 5/28).The study is available online.
Digital media are changing the environment for communicating health information. In a new book, "Health Communication and the New Media Landscape," University of Missouri journalism researchers examine how the digital media revolution is affecting health and health care in the United States. Effective health communication can significantly enhance health care and public health as well as reduce inequities in people"s access to health information and services, according to the authors.
To help customers have a safe and fun summer in the sun, Rite Aid and The Skin Cancer Foundation are partnering to raise awareness and offer free information on the importance of smart skin care practices. A free skin care guide aimed to encourage customers to protect their skin this summer will be available at nearly 4,900 Rite Aid stores nationwide and online at http://www.riteaid.com starting May 31.
Clinipace, a digital clinical research organization, announced that Inspire Pharmaceuticals, Inc. has selected the company to manage and deploy two phase II studies for the ophthalmic prescription medicine, AzaSite®.
Two studies in the May 29th issue of Cell, a Cell Press publication, have taken advantage of new technological advances to search for and find previously unknown weaknesses in a hard to treat form of cancer. The discoveries lend new hope in the fight again tumors that are today considered "undruggable."
Boehringer Ingelheim announced today that it will become the founding sponsor of the World Stroke Academy, a novel training initiative for stroke professionals being developed by the World Stroke Organization (WSO). This latest educational initiative from the WSO will bring together an international group of stroke experts - led by Professor Michael Brainin of the Danube University Krems, Austria - to provide information about stroke and knowledge for health professionals and medical doctors in order to improve prevention, therapy and management of stroke.
Viewing a video showing a patient with advanced dementia interacting with family and caregivers may help elderly patients plan for end-of-life care, according to a study led by Massachusetts General Hospital (MGH) researchers. In their report in the journal BMJ, released online, the investigators find that participants who watched such a video in addition to listening to a verbal description of the condition were more likely to indicate they would choose only comfort care if they developed advanced dementia and also said they felt the video was helpful to their decision-making process.
When someone becomes dependent on drugs or alcohol, the brain"s pleasure center gets hijacked, disrupting the normal functioning of its reward circuitry.
We all know that vitamin D and calcium are good for bones, but research teams in Europe and USA have shown that both taken daily reduces the rate of hip fracture in older people by 20%.
Oxidative stress has been linked to aging, cancer and other diseases in
The Centre for Epidemiological Studies into Sexually-Transmitted Diseases and AIDS in Catalonia (CEEISCAT) started a pioneering study in Spain in 2005 to look into the prevalence of sexually-transmitted diseases (STDs) among female sex workers (SWs). The objective was to monitor the rates of infection with both HIV and other diseases over time, as well as the prevalence of risky behaviour.
Small Bone Innovations, Inc. (SBi), a leading provider of innovation, products, technology and education for the small bone & joint segment of the orthopedics industry, announced that the U.S. Food and Drug Administration (FDA) has approved SBi"s Scandinavian Total Ankle Replacement (S.T.A.R.®) system to treat U.S. patients. S.T.A.R. has received pre-market approval (PMA) to replace a painful arthritic ankle joint due to osteoarthritis, post-traumatic arthritis or rheumatoid arthritis.
The European Medicines Agency has been formally notified by BioPartners GmbH of its decision to withdraw its application for Biferonex (interferon beta-1a), 6 million-international-unit solution for injection, prefilled syringes for subcutaneous administration.
The New Zealand Medical Association (NZMA) welcomed today"s Budget which reaffirms the Government"s commitment to solving our long term health workforce problems.
Although a large number of children"s hospitals have developed or are developing policies regarding organ donation after cardiac death, there is considerable variation among policies, including the criteria for declaring death, according to a study in the May 13 issue of JAMA.
Half a million people in the UK have undiagnosed coeliac disease
Ethicon Endo-Surgery today announced that the Anesthesiology and Respiratory Therapy Devices Advisory Committee of the U.S. Food and Drug Administration (FDA) voted in favor of approval of the SEDASYS(R) System for use by physician/nurse teams to administer minimal-to-moderate propofol sedation during screening and diagnostic procedures for colorectal cancer (colonoscopy) and the upper gastrointestinal tract (EGD). The SEDASYS(R) System, the first computer-assisted personalized sedation (CAPS) system, integrates drug delivery and patient monitoring to enable propofol sedation personalized to each patient"s needs.
CAFFEINE SHOWN AS EFFECTIVE AT REDUCING EXERCISE-INDUCED ASTHMA SYMPTOMS AS AN ALBUTEROL INHALER
Although heart failure is a chronic condition, acute exacerbations are frequent and occur with serious complications; patients with heart failure and their families can help improve prognosis in acute events if they are taught to recognise the tell-tale signs of worsening condition and seek immediate medical help. "Any delayed recognition of these signs is associated with an increased rate of hospitalisation and complications, including mortality," says Professor Ferenc Follath from the University Hospital of Zurich, Switzerland.
A new, international study found that the combination of two drugs delays disease progression for patients with advanced non-small cell lung cancer (NSCLC). Results from the Phase III "ATLAS" trial were presented today by Dr. Vincent Miller of Memorial Sloan-Kettering Cancer Center (MSKCC) at the American Society of Clinical Oncology Annual Meeting.
The following summarizes selected women"s health-related blog entries.~"Considering Common Ground and Our New Supreme Court Nominee," Cristina Page, Birth Control Watch: Page writes that the fact that appeals court Judge Sonia Sotomayor, Obama"s nominee to replace retiring Supreme Court Justice David Souter, has served on the board of Childbirth Connection is of great interest, since Sotomayor"s own views on women"s health could mirror those of the organization. Page explains that the organization "takes no policy position on abortion, but it is very much a proponent of women"s rights during childbirth." According to Page, Sotomayor"s work with Childbirth Connection "stands out" on her resume as "the only entry that does not have a purely legal focus." Page writes, "To me, it"s an important sign, and one from which pro-choice and women"s health advocates can derive some comfort," as the group is "dedicated to identifying and promoting best practices in women"s health based on rigorous scientific evidence." She adds, "If Sotomayor"s connection to the group is any indication of the value she places in science and her respect for the field of medicine, her nomination is good news for women"s health." Page also provides a link to audio of her appearance on a radio show to discuss "common ground" in the abortion-rights debate. She writes that David Gushee, an abortion-rights opponent who also appeared on the show, was genuinely "reasonable and looking for solutions." Page adds, "Listening to him gives me faith in this new and albeit small movement of pro-lifers who genuinely want to support policies that help reduce the need for abortion" (Page, Birth Control Watch, 5/27).~ "Unshackling Female Prisoners in Labor," Abigail Kramer, Salon"s "Broadsheet": Last week, the New York state Legislature passed a measure that would prevent the state"s prisons from using handcuffs or shackles on pregnant female inmates during labor. Similar laws exist in three other states. Kramer writes, "Handcuffs and shackles for women in labor pose problems beyond the obvious snafu of being brutal, inhumane and bat"s balls freaking crazy." She continues, "Having a baby is generally understood to be a wee bit uncomfortable," adding, "Not being able to move can increase the pain and slow down or complicate labor" and "restraints can cause a delay if a woman has to be rushed off for an emergency C-section -- which, as a doctor points out in Amnesty"s original report on institutional violence against women prisoners, can lead to brain damage for the baby." In addition, "women giving birth have not turned out to pose a tremendous flight risk to the nation"s criminal [justice] system: When Amnesty International asked prison administrators to provide examples of past in-labor escape attempts, they came up with exactly... well, zero," Kramer concludes (Kramer, "Broadsheet," Salon, 5/28).~ "Be Responsible: Give Your Partner Drugs!" Norah Hazelton, National Family Planning & Reproductive Health Association"s "Family PlanIt": "One thing I remember pretty clearly from sex ed in high school health class ... was that if one person in a couple is diagnosed with an [sexually transmitted infection] and gets treatment, it"s very important to get the other partner tested and treated because otherwise you can just end up passing it back and forth," Hazelton writes. She continues, "Trouble is, a lot of STIs don"t have symptoms and it can be difficult getting someone with no symptoms to take the time (and money) to go see a doctor." Hazelton writes, "Thankfully, expedited partner therapy (EPT), the practice of treating partners without a medical assessment, is becoming more and more popular." She adds, "With 19 million new cases of STIs each year in the U.S. (costing an estimated $15.9 billion annually), any options that could reduce those numbers need to be considered seriously." Although the Centers for Disease Control and Prevention has recommended and endorsed EPT, "there are still many legal barr
Aetna, Cigna and Humana ranked highest nationally on criteria including speed of health claim payments and fewest claims denied, according to the 2009 PayerView Rankings, the Boston Globe reports. The rankings -- prepared by Athenahealth in collaboration with Physicians Practice management journal -- evaluated 172 national, regional and government payers in 40 states.According to the data, insurers paid physicians an average 5.3% faster in 2008 and denied an average of 9% fewer medical claims compared with 2007 figures. On average, national health insurers paid physicians in 33 days and denied 9.2% of claims.According to the Globe, the rankings reveal some of the obstacles that can result from the complexities and bureaucracy involved in the medical billing process, with each insurer operating in different ways. Jonathan Bush, chair and CEO of Athenahealth, said, "This is the biggest problem we have in health care -- the inability to close supply chains and to practically and tactically connect doctors with payers and patients," adding, "These connections are broken" (Weisman, Boston Globe, 5/28).
National HIV prevention strategies in at least five African countries are not reaching the groups most at risk of infection, according to a report from UNAIDS and the World Bank conducted in conjunction with the national HIV/AIDS authorities of Kenya, Lesotho, Mozambique, Swaziland and Uganda, IRIN/PlusNews reports. The study was conducted between 2007 and 2008 to determine how and where most HIV cases were occurring in each country. It also aimed to examine whether prevention programs and spending aligned with those findings. According to the report, most prevention initiatives are not based on evidence of the behaviors that spread HIV in the five surveyed countries. For example, most new infections in Lesotho occur because of concurrent sexual partnerships, both before and after marriage. However, the country does not have any prevention strategies aimed at concurrent partnerships, or couples who are married or in long-term relationships. In addition, the report found that in Mozambique, an estimated 19% of new HIV infections were spread through commercial sex work, 3% from injection drug use and 5% among men who have sex with men. According to the report, few programs in the country target sex workers, while none are tailored to IDUs or MSM. According to the report, spending on HIV prevention often is low in the surveyed countries. Lesotho spends 13% of its national HIV/AIDS budget on prevention, while Uganda spends 34%. Director of the World Bank"s Global HIV/AIDS Unit Debrework Zewdie said that the economic downturn makes it important to maximize the impact of HIV prevention investments. "These syntheses use the growing amounts of data and information available to better understand each country"s epidemic and response and identify how prevention might be more effective," she said. The report includes recommendations on how the surveyed countries can better implement evidence-based prevention efforts. It said that Lesotho should revise its prevention messages to address multiple concurrent partnerships and integrate the subject into future initiatives. In addition, Mozambique should focus condom promotion on groups such as sex workers, the report said. According to IRIN/PlusNews, the five-country program aims to enhance capacity to ensure that the countries can conduct similar studies in the future (IRIN/PlusNews, 5/27).
Researchers at UC Santa Barbara have recently demonstrated a breakthrough in the quantum control of photons, the energy quanta of light. This is a significant result in quantum computation, and could eventually have implications in banking, drug design, and other applications.
A case report written by Dr Francesco Natale and his colleagues, from the Second University of Naples and Monaldi Hospital, Naples, Italy, reports on the dangers of stimulant chewing gums containing caffeine. The report published in this week÷´s edition of The Lancet describes the story of a teenage boy hospitalized after excessive consumption of this type of product. The authors warn about the high risks of stimulant chewing gums that are widely available to children.
The New York Stem Cell Foundation (NYSCF) announced the award of four new NSYCF-Stanley and Fiona Druckenmiller Fellows. These New York-based post-doctoral scientists join 13 extraordinarily accomplished stem cell researchers from leading research institutions who have been supported by the fellowships program since 2006.
Focusing HIV drug development on immune cells called macrophages instead of traditionally targeted T cells could bring us closer to eradicating the disease, according to new research from University of Florida and five other institutions.
If you are a clinical research novice or veteran with a study sponsor, research site, or CRO in a corporate, academic or other organization, you will find a comprehensive program that focuses on your current needs and broadens your knowledge. MAGI conferences feature balanced co-presentations from sponsors, sites and CROs, real-life examples, practical tips, and lots of interaction and networking. This year"s conference will feature:
A 15-year whistleblower case filed by a former employee against Healthways, Inc. has been settled for approximately $40,000,000 in damages and fees. The case was initiated in June 1994, when A. Scott Pogue, who had recently been fired from his job as a marketing representative for a company called Diabetes Treatment Centers of America, filed a case in Nashville under the United States Civil False Claims Act against his former employer.
GTCbio Announces 4th Annual Assay Development and Screening Conference taking place June 8-9, 2009. As compounds derived from high throughput screening increasingly find their way into clinical trials, drug screening has become widely accepted as a critical step in the drug discovery process. After more than a decade of rapid growth, tremendous progress has been made in assay technology, laboratory automation, and informatics. These technological developments have not only facilitated a drastic increase in throughput and efficiency in drug screening, but have also provided novel solutions in other areas of drug discovery and development. As screening has also become prominent in biological research, screening facilities have become increasingly popular in academic institutions.
Following calls from the information commissioner for the NHS to improve its data security, after breaches involving the loss of thousands of personal medical records, Bill Gilliam, head of the health sector group at international law firm Eversheds comments:
Boehringer Ingelheim will present new data on the company"s two lead oncology compounds, BIBW 2992* and BIBF 1120** at the 2009 Annual Meeting of the American Society of Clinical Oncology (ASCO), the company announced today. Two studies in the LUX-Lung clinical development programme for BIBW 2992 and a Phase II study of BIBF 1120 in ovarian cancer patients will be presented.
The Alabama Department of Public Health has confirmed its first novel H1N1 influenza cases in
MDS Nordion, a leading global provider of medical isotopes and
An editorial and a case report on Disorders of Sexual Development (DSD) in the Medical Journal of Australia highlight the need for early diagnosis and effective risk management in these rare but potentially life threatening cases.
XClinical, a European vendor of innovative software products for eClinical trials, is presenting CDISC based tools for an End-To-End clinical process at the 45th DIA Annual Meeting in San Diego, USA.
With consumer genetics becoming more of a reality to the average consumer and direct-to-consumer (DTC) genetics tests becoming more available, thought leaders, experts and DTC companies will convene in Boston on June 9-11 for the first annual Consumer Genetics Conference to move the issues to the forefront and demystify this emerging field. Preeminent leaders from government, healthcare, biotechnology and diagnostic fields, will examine consumer genetics, including its practical realities and complex policy considerations; speakers and companies will present new advances and information on available genetic tests and developments in this field. The conference is open to all who are curious, impacted by, and interested in consumer genetics, including consumers (http://www.consumergeneticsconference.com).
Poniard announced positive Phase II data from its two trials in CRC and CRPC with picoplatin this morning, including efficacy that was comparable to the current standard of care, with a significantly improved safety profile. We believe that these data provide further evidence of picoplatin"s favorable efficacy and safety profile in two more large oncology markets, in addition to SCLC, and position picoplatin as a platform treatment that can provide solutions in multiple oncology settings. We believe that given these data from CRC and CRPC, in addition to the anticipated Phase III SPEAR data in SCLC, will attract the interest of multiple players and we expect that Poniard will be able to at least secure a large pharma partnership sometime this summer, unless a company like Sanofi (SNY Not Rated), Takeda (TKD Not rated), or Bristol-Myers Squibb (BMY Not Rated) decide to step in and acquire the whole company, for rights to both the IV and oral version of picoplatin.
Around one in five hospital patients who have trouble feeding themselves do not get help with meals, according to the survey released by the Care Quality Commission (CQC).
Bayer HealthCare Pharmaceuticals, Inc. and Onyx Pharmaceuticals, Inc. (Nasdaq: ONXX) announced that the companies have begun enrolling patients in an international Phase 3 trial to evaluate Nexavar(R) (sorafenib) tablets in patients with non-squamous non-small cell lung cancer (NSCLC) who have failed two or three previous treatments.
A vaccine for one of the most lethal cancers, advanced melanoma, has shown improved response rates and progression-free survival for patients when combined with the immunotherapy drug, Interleukin-2, according to researchers from The University of Texas M. D. Anderson Cancer Center.
About half of all people who have a major stroke following a warning stroke (a transient ischemic attack or mild stroke) have it within 24 hours of the first event, according to research published in the June 2, 2009, print issue of Neurology®, the medical journal of the American Academy of Neurology.
Unwed pregnant teens and twenty-somethings who attend or have graduated from private religious schools are more likely to obtain abortions than their peers from public schools, according to sociological research published in the June issue of the Journal of Health and Social Behavior.
Infants and young toddlers with obstructive sleep apnea and sleep disordered breathing experience significant improvement following surgical treatment of the ailment, according to an invited article in the June 2009 issue of Otolaryngology-Head and Neck Surgery.
Stem cells containing protective genes may provide permanent control of human immunodeficiency virus (HIV) in infected individuals, according to research presented at the American Society of Gene Therapy 12th Annual Meeting, May 30.
Obesity is an independent predictor of inadequate bowel preparation at colonoscopy, and the presence of additional risk factors further increases the likelihood of a poorly cleansed colon, according to a new study in Clinical Gastroenterology and Hepatology, the official journal of the American Gastroenterological Association (AGA) Institute.
The world"s largest ear, nose, and throat professional medical association, the American Academy of Otolaryngology - Head and Neck Surgery (AAO-HNS), has released a manual detailing best practices for the creation of new clinical practice guidelines. The manual is published as a supplement to the June issue of Otolaryngology - Head and Neck Surgery.
If you had cancer and a genetic test could predict the risk of the tumor spreading aggressively, would you want to know - even if no treatments existed to help you?
Findings in mice suggest greater hope for targeting brain cancer, but also greater caution in pursuing stem cell treatments for degenerative diseases
A mineral found at health food stores could be the key to developing a new line of antibiotics for bacteria that commonly cause diarrhea, tooth decay and, in some severe cases, death.
The June issue of Ophthalmology, the journal of the American Academy of Ophthalmology, includes new insights on why some corneal transplants fail, why some patients skip their glaucoma medications, and why preventing infections after LASIK is a growing concern.
Exelixis, Inc. (Nasdaq: EXEL) today reported encouraging data from an ongoing Phase 1 dose-escalation trial of XL228 in patients with advanced malignancies. XL228 is a small molecule inhibitor of insulin-like growth factor type 1 receptor (IGF1R), SRC, Aurora kinases, and fibroblast growth factor receptor types 1, 2, and 3 (FGFR1-3), which are associated with cancer cell proliferation, survival, and metastasis. The compound also inhibits BCR-ABL, including the T315I mutant form which is resistant to currently approved inhibitors. David Smith, MD, Professor of Medicine at the University of Michigan, an investigator on the Phase 1 trial, will present the data in an oral session (Abstract #3512) beginning at 4:15 p.m. local time on Saturday, May 30, 2009, at the American Society of Clinical Oncology Annual Meeting, which is being held May 29-June 2 in Orlando.
ChemGenex Pharmaceuticals Limited (ChemGenex) (ASX:CXS) announced that the latest data from its pivotal study of omacetaxine in patients with T315I-positive chronic myeloid leukemia (CML) was the subject of an oral presentation and discussion at the 2009 American Society of Clinical Oncology (ASCO) Annual Meeting in Orlando, Florida. The open label Phase 2/3 study (CGX-635-CML-202) investigated the use of omacetaxine, administered subcutaneously in CML patients who had failed imatinib and who have the highly drug resistant T315I kinase domain mutation.
Insurance companies, "the industry that gets credit for helping to kill the Clinton administration"s health care overhaul 15 years ago," are now "striking a conciliatory tone as it faces the most serious attempt to overhaul the system since that effort collapsed," CQ Politics reports. With low favorability ratings and Democrats in control of the federal government, "insurers know they aren"t in a good bargaining position" this time around. They have already offered concessions, including providing "insurance in the individual markets to everyone, without regard to who is sick," and not "charging people who are ill higher rates and cut health care costs." But they"ve also been ""careful to structure their offers in such a way that appears significant but does not overpromise." An individual mandate for all Americans and an end to health screening for applicants could offer "a win-win outcome, one that will benefit not just patients but potentially the profits of the industry as well." But "perhaps the biggest motivation for insurers to deal now is that they fear what might happen if they don"t" - the "creation of a government-run plan that would be more attractive to the public and siphon off customers" (Adams, 6/1).
BioLineRx Ltd. (TASE:BLRX), a clinical stage drug development company, today announced positive preliminary results from the ongoing phase I/II clinical trial designed to assess the safety and feasibility of BL-1040, the first injectable device designed to address cardiac remodeling, in 20- 30 patients at several sites in Germany and Belgium. To date, 15 patients were successfully treated with BL-1040 with no complications. Moreover, six months follow up results from the first 5 patients show BL-1040"s efficacy in preventing cardiac remodeling and preserving cardiac function.
The Wall Street Journal reports that "the federal government is stepping up efforts to improve the quality of nursing-home care and now has an online tool consumers can use in evaluating facilities. The Centers for Medicare and Medicaid Services, or CMS, will begin a pilot program this summer to see if cash incentives to nursing homes can improve the care they provide, especially in areas such as nurse staffing and preventable hospitalizations."
Olympus America Inc. has expanded its medical portfolio by introducing the X-Suit NIR®, a biliary metallic stent designed with exceptional anatomic conformability and superior radial support. The X-Suit NIR"s proprietary NIRflex™ cell design provides a physician support and flexibility; both critical to help relieve the symptoms associated with pancreatic, liver and bile duct cancers.
The National Institute of Mental Health has awarded Group Health a $1 million stimulus grant to research more effective treatment for depression. The award is part of the federal stimulus funds from ARRA, the American Recovery and Reinvestment Act of 2009.
The damage that our modern living and working environment could be doing to our health will be investigated by a new ÷£5M MRC-HPA Centre for Environment and Health at Imperial College London and King"s College London.
StemCells, Inc. (NASDAQ:STEM) announced plans to present data from its Phase I clinical trial of its proprietary HuCNS-SC® product candidate (purified human neural stem cells) at the 12th International Congress on Neuronal Ceroid Lipofuscinoses (NCL) being held June 3 - 6, 2009 in Hamburg, Germany. Stephen Huhn, MD, FACS, FAAP, vice president and head of the Company"s CNS program, is scheduled to present the data on Saturday, June 6.
In an effort to increase the public"s awareness of the health consequences of cigarettes, the WHO on Friday called on international governments to require that cigarette packages feature images of the harmful effects smoking can have on the body, the AP/Google.com reports (Klapper, AP/Google.com, 5/29).
Sepracor Inc. (Nasdaq: SEPR) today announced that it has been notified by the U.S. Food and Drug Administration (FDA) that the New Drug Application (NDA) for STEDESA™ (eslicarbazepine acetate) has been accepted for filing and is now under formal review. As previously announced, the NDA for STEDESA was submitted to the FDA on March 31, 2009 for adjunctive therapy in the treatment of partial-onset seizures in adults with epilepsy. The acceptance of the filing means that the FDA has made a threshold determination that the NDA is sufficiently complete to permit a substantive review.
A group of Senate Democrats will meet with President Obama today to discuss overhauling health care, The New York Times reports.
Health care costs soared nearly 50 percent between 2000 and 2006, adding an urgency for reform that may help Democrats pass a major overhaul before the year-end deadline set by the White House, Bloomberg reports. "You come to a point where you can"t afford health care as it is and you have to reform it," Rep. John Dingell, D-Mich., told Bloomberg. As Congress seeks to capitalize on spending growth, industry groups have arrived at the table with their own suggestions for cutting up to $1.7 trillion in spending over the upcoming decade (Litvan, 6/2).
This month"s Journal of Aerosol Medicine and Pulmonary Drug Delivery features positive Phase Ib clinical trial results for PARI Pharma"s L-CsA, inhaled liposomal cyclosporine A. In May, PARI Pharma received Orphan Drug Designation from the Food and Drug Administration for L-CsA, delivered via an Investigational eFlow Nebulizer System, for the prevention and treatment of bronchiolitis obliterans, a devastating, incurable disease of the small airways affecting approximately 60,000 patients worldwide.
Hyperion Therapeutics, Inc. announced top-line results from a phase I study of HPN-100 in patients with liver cirrhosis. The data were presented as part of the 2009 Digestive Disease Week meeting. The abstract is titled "Pharmacokinetic (PK) and Safety Analyses of a Novel Ammonia-Reducing Agent in Healthy Adults and Patients with Cirrhosis."
Reuters reports that, due to the difficulties in getting or paying for health insurance, "countless workers in the United States are trapped in jobs they would like to leave ... calcifying innovation and mobility in the world"s largest economy." Reuters notes that when he was head of the National Federation of Independent Businesses, "Todd Stottlemeyer frequently encountered would-be entrepreneurs who let their ideas go stale and their products languish on the workbench because they did not want to shoulder their own health care costs. "
Varian Medical Systems (NYSE: VAR) will be demonstrating its full range of brachytherapy cancer treatment equipment and software at the American Brachytherapy Society meeting in Toronto, Canada, from May 31 to June 2. Varian"s exhibit will include the new BrachyVision™ Acuros™ system, which offers a significantly more accurate* way of calculating the dosimetry of cancer treatments.
Research from a survey by Tesco Dental Insurance has revealed Brits are finding it increasingly difficulty to find an NHS dentist. The results also show that rising dental costs are putting people off visiting the dentist.
The following summarizes selected women"s health-related blog entries.~ "The Murder of Dr. Tiller, a Foreshadowing," Cristina Page, Birth Control Watch: Page writes, "For those who would like to think" that the "murder in church of Dr. George Tiller ... is an isolated incident, here"s the horrifying news: You are wrong." She continues, "The pattern is clear and frightening." According to Page, there were several murders of abortion providers and even more attempted murders during the administration of former President Clinton, the first president to support abortion rights. However, during the Bush administration, "not only were there no murders, there were no attempted murders," save for a single bombing of an abortion clinic, according to Page. She writes that Tiller"s murder occurred five months into the administration of President Obama, the nation"s second president who supports abortion rights. Page adds, "One can only conclude that like terrorist sleeper cells, these extremists have now been set in motion. Indeed the evidence is already there. The chatter, the threats, the hate-filled rhetoric, are abundant." According to Page, "The pro-choice movement, specifically our abortion providers, are in the greatest danger of violence when we take power." She adds, "The murder of Dr. Tiller suggests that violence against abortion providers may be far more linked to the power, or lack thereof, antiabortion groups have politically than to laws designed to increase penalties against such acts." Page continues that abortion-rights opponents "will put out carefully worded press statements condemning the murder of Dr. Tiller, as became routine for them during the Clinton years." Page concludes, "But unless the rhetoric they choose from now on becomes careful too -- they may be the enablers of murder and terror" (Page, Birth Control Watch, 5/31).~ "Where Will Women Go Now?" Kate Harding, Salon"s "Broadsheet": "If any good can come of the murder of Dr. George Tiller, ... perhaps it"s the opportunity to have a conversation about the reality of termination in the second and third trimesters," Harding writes. She adds, "Anti-choice activists often cast late-term abortions as the murder of a viable baby at the whim of a woman who doesn"t wish to be inconvenienced, carried out by a doctor who looks at her and sees only cartoon dollar signs." According to Harding, "such misinformation and outright lies about procedures that are in fact rare and only performed when medically necessary are what led anti-choice activists to call Tiller "America"s Doctor of Death" and accuse him of running a "murder mill."" The "reality" is that Tiller helped "women in absolutely desperate circumstances, when almost no one else would," Harding writes, adding, "Since the news of Dr. Tiller"s murder broke, personal narratives from people who used his services have been appearing around the Web." Harding talked to Susan Hill, president of the National Women"s Health Foundation, which referred girls and women to his clinic. Hill said, "We always sent the really tragic cases to Tiller." Harding reports that these included "women diagnosed with cancer who needed abortions to qualify for chemotherapy, women who learned late in their pregnancies that their wanted babies had fatal illnesses and rape victims so young they didn"t realize they were pregnant for months." According to Harding, "The trauma of receiving such a diagnosis is only compounded by the difficulty of obtaining a late-term abortion." Harding asked Hill "where women who need late-term abortions can go now," and says that Hill"s "response was bleak." Hill added that she doesn"t know where she will send "those really tragic cases"(Harding, "Broadsheet," Salon, 6/1). ~ "How I (and Other "Pro-Life" Leaders) Contributed to Dr. Tiller"s Murder," Frank Schaeffer, Huffington Post blogs: "My late father and I share the blame (with many others) for the murder of Dr. George Tiller," Schaeffer writes, adding, "Until I got out of the r
The first artificial organ for liver patients that uses immortalized human liver cells, the Extracorporeal Liver Assist Device, or ELAD®, is a bedside system that treats blood plasma, metabolizing toxins and synthesizing proteins just like a real liver does.
The prevalence of overweight in the US population is among the highest in Mexican-American children and adolescents. In a study of 1,030 Hispanic children between the ages of 4 and 19, published in the June 2009 issue of the Journal of the American Dietetic Association, researchers from the Baylor College of Medicine found less than optimal diets in both overweight and non-overweight participants.
Researchers present the latest advances in a technology that continues to change the face of gastroenterology and surgery, known as Natural Orifice Translumenal Endoscopic Surgery®, or NOTES®, at Digestive Disease Week® 2009 (DDW®). NOTES eliminates the need for incisions and allows for less pain and scarring associated with traditional laparoscopic surgery along with a much faster recovery time for the patient. Study findings and video demonstration will illustrate the most recent NOTES applications including cholecystectomy, appendectomy and gastrectomy. DDW is the largest international gathering of physicians and researchers in the fields of gastroenterology, hepatology, endoscopy and gastrointestinal surgery.
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External beam partial breast irradiation (EB-PBI) is the most cost-effective method for treating postmenopausal women with early-stage breast cancer based on utilities, recurrence risks and costs when compared to whole breast radiotherapy (WBRT) and brachytherapy partial breast irradiation (brachy-PBI), according to a study in the June 1 issue of the International Journal of Radiation Oncology*Biology*Physics, the official journal of the American Society for Radiation Oncology (ASTRO).
Researchers at Penn State College of Medicine, working with biochemists, geneticists and clinicians at the University of Bern, Switzerland and in the United Kingdom, have discovered an enzyme that has a key role in inflammatory bowel disease (IBD). The team, co-led by Judith Bond, Ph.D., Distinguished Professor and Chair of Biochemistry and Molecular Biology at Penn State College of Medicine, and Daniel Lottaz, Department of Rheumatology and Clinical Immunology at the University of Bern, Switzerland, could potentially lead to therapies to help the half-a-million Americans affected by ulcerative colitis and Crohn"s disease, collectively referred to as IBD.
Researchers are calling for space headache to be established as a new secondary disorder after carrying out a study of 17 astronauts, published in the June issue of Cephalalgia.
As part of its community outreach, Breast Cancer Help, Inc. attended the annual National Breast Cancer Coalition (NBCC) conference, which was held May 2-5 at Washington, D.C. Representatives of Breast Cancer Help, along with hundreds of other activists, met at the nation"s capital to meet with elected officials who are responsible for the majority of the funding for breast cancer research. The conference was held to challenge the newly elected leaders in Washington to create the changes necessary to ensure the much-needed funding for research and access to quality care.
Working with a population of individuals at risk for gastrointestinal cancers, researchers at Fox Chase Cancer Center have learned that many people misjudge their actual degree of cancer risk and, therefore, their true need for prevention support. Strategies for accurately assessing cancer risk are critical for appropriately targeting educational, counseling, and diagnostic res to prevent cancer in as many individuals as possible, the investigators say.
Despite what some may think, people aren"t hiding their use of BOTOX® Cosmetic and hyaluronic acid dermal fillers. In fact, according to survey statistics released today by The Aesthetic Surgery Education & Research Foundation (ASERF), the research arm of the American Society for Aesthetic Plastic Surgery (ASAPS), nearly nine out of 10 respondents (87 percent) openly discuss their BOTOX® Cosmetic and hyaluronic acid dermal filler treatments with others, with seven out of ten (70 percent) receiving support from the people they told.
While most nutrition experts agree that school lunches should include more whole-grain products, a new study from the University of Minnesota finds that food-service workers lack understanding and the res to meet that goal.
Infertility Network Scotland has welcomed the announcement by the Public Health Minister, Shona Robison, that over the next three years the Scottish Government will provide funding to Infertility Network Scotland to work with Health Boards to help them to address the inequity of access that has existed in Scotland for too many years. We also welcomed the news that an expert advisory group will be established this summer to consider an action plan on infertility services.
The European Society of Cardiology Congress 2009, the world"s biggest international meeting in Cardiology will be held in Barcelona, Spain, from 29 August to 2 September.
An innovative University of Georgia graduate program in special education that has prepared scores of Georgia teachers to work with elementary-age students with autism over the last several years has received a new 4-year, $793,000 federal grant to train teachers to work with similarly challenged secondary-age students.
Medical schools nationwide struggle to recruit minority physicians, but Temple has met that challenge head on and has the record to prove its success.
A national Radiation Therapy Oncology Group (RTOG) study led by a Medical College of Wisconsin Cancer Center physician at Froedtert Hospital in Milwaukee has found that a course of radiation therapy to the brain after treatment for locally advanced non-small cell lung cancer reduced the risk of metastases to the brain within the first year after treatment. The study was presented at the American Society of Clinical Oncology annual meeting in Orlando, June 1.
Researchers from the Brigham and Women"s Hospital and Harvard Medical School in Boston have released a 22-year study that reports Hispanic patients have poorer outcomes following infrainguinal bypass grafting for the treatment of peripheral arterial disease (PAD). Results showed that of all the study participants, Hispanics had a higher rate of bypass graft failure and amputation after revascularization compared to Caucasians. In an analysis that accounted for a myriad of important variables affecting limb salvage after bypass, Hispanic ethnicity was found to be independently predictive of eventual amputation. Details of the study appear in the Society for Vascular Surgery"s(R) June 2009 issue of the Journal of Vascular Surgery(R).
Some liberal journalists and bloggers are criticizing Fox News host Bill O"Reilly for the language he has used when discussing abortion provider George Tiller, with some suggesting that his harsh rhetoric incites violence, the New York Times reports. Tiller, who was one of a small number of U.S. doctors who performed abortions later in pregnancy, was shot and killed on Sunday while serving as an usher in his local church. On Monday, O"Reilly said that "clear-thinking Americans should condemn" the murder but also defended his past remarks about Tiller. O"Reilly said that "every single thing we said about Tiller was true, and my analysis was based on those facts."Salon within nine hours of Tiller"s death had posted video clips of 29 on-air references that O"Reilly had made about Tiller on past programs. O"Reilly has said that Tiller and other abortion providers conduct the "business of destruction" and that he "wouldn"t want to be these people if there is a Judgment Day." Media Matters for America on its site published a 2006 clip in which O"Reilly said, "If I could get my hands on Tiller," adding, "Well, you know. Can"t be vigilantes. Can"t do that. It"s just a figure of speech."According to the Times, O"Reilly often draws particular attention because his cable news show has held a No. 1 rating for the past seven years. Burt Neuborne, a New York University law professor and a former legal director for the American Civil Liberties Union, said that a commentator"s language, regardless of its severity, usually cannot be treated as an incitement of violence unless it includes direct instructions to individuals. He added, "It"s important not to allow that to happen. It would have a dramatic effect on the ability to speak vigorously" (Stelter, New York Times, 6/2).
The San Francisco Chronicle reports that Sen. Max Baucus, D-Mont., will meet with supporters of a single-payer health system Wednesday to discuss their ideas on health reform.
"With a health reform at the top of the Congressional and White House agenda, it"s prime time for industry lobbyists," Roll Call reports. But, because details of the anticipated reform package have not yet emerged, industry winners and losers remain largely unknown. Lobbyists are forced to accept clients despite their incomplete knowledge of client needs, and are struggling to anticipate conflicts of interest before they arise, according to the article. "There are so many different players at the table, and right now not knowing whose ox is likely to get gored and at whose expense... the best we can do is try and anticipate conflicts and be clear with our clients in advance," one health care lobbyist told the paper. "We certainly would not lobby on both sides of an issue. It"s also entirely possible conflict may emerge in the next two to six months, and we hope we don"t have to make hard choices" (Ackley, 6/3).
"Mayor Michael R. Bloomberg and city labor officials announced a tentative agreement Tuesday to amend health benefits for more than 550,000 current and retired city employees, guaranteeing the city $400 million in savings over the next two fiscal years," The New York Times reports. The arrangement imposes "$50 to $100 co-payments for about one-fifth of current and retired city employees, and eliminates coverage for preventive dental care at certain offices." The paper adds, "For most other city employees, the plan would restrict certain hospital, ambulatory and hemodialysis coverage to network providers and would implement several other administrative cost-saving measures." The agreement requires union approval.
Researchers at the University of Tennessee Health Science Center (UTHSC) are recruiting participants for a national clinical study of medication that could slow the progression of Parkinson"s disease. The study, referred to as "QE3," will examine the effectiveness of the research medication Coenzyme Q10 (CoQ). During the study, investigators will administer high doses of CoQ to participants 30 years of age or older with early stage Parkinson"s disease to reduce the speed of their physical decline. The research is sponsored by the National Institute of Neurological Disorders and Stroke, a division of the National Institutes of Health (NIH), and will be conducted by the Parkinson Study Group, an international council of physicians and researchers experienced in caring for Parkinson"s patients and studying the disease.
Genes trump environment as the primary reason that some adolescents are more likely than others to be victimized by crime, according to groundbreaking research led by distinguished criminologist Kevin M. Beaver of The Florida State University.
The Premier healthcare alliance applauds the healthcare stakeholders group for their commitment to achieve up to $2 trillion in savings over the next decade.
The new H1N1 swine flu virus claimed the life of a 20-year old Chicago woman on Saturday, one day after giving birth to a baby via Cesarean
GameStop (NYSE: GME) teamed with the National Women"s Health Re Center (NWHRC) to provide five key practical health tips for women in their 20s. The national video game retailer also asked 20-something celebrities Cote de Pablo (NCIS) and Michelle Trachtenberg (17 Again) to share their personal fitness tips as well. These tips and more health and fitness information can be found at http://www.gamestop.com/fitatanyage.
TomoTherapy Incorporated (NASDAQ: TOMO) announced that the University of Kentucky (UK) Chandler Medical Center"s Markey Cancer Center has commenced treating patients with the TomoTherapy® Hiò€¢Art® treatment system, a versatile, CT scanner-based device, which integrates image guidance for increased treatment accuracy and helical radiation therapy delivery for enhanced tumor targeting. The Hiò€¢Art treatment system was selected after a thorough review of technologies and will be extensively utilized in the Markey Cancer Center"s stereotactic body radiation therapy (SBRT) efforts, as part of its new Brain and Body Radiosurgery Program.
A simple magnetic resonance imaging (MRI) test involving breathing oxygen might help oncologists determine the best treatment for some cancer patients, report researchers at UT Southwestern Medical Center.
Enzo Biochem, Inc. (NYSE: ENZ), a biotechnology company specializing in gene identification and genetic and immune regulation technologies for diagnostic and therapeutic applications and laboratory services, announced that data from a Phase II clinical trial was presented today at Digestive Disease Week, the largest international gathering of academic researchers and practicing physicians in gastrointestinal medicine, held this year in Chicago. The data indicate that Alequel™, the Company"s investigational individualized oral immune regulation preparation, may be effective for the treatment of moderate-to-severe Crohn"s disease.
Over the past 20 years, the health care system has made tremendous progress in reducing the use of physical restraints among hospitalized elderly patients, a positive change that has had numerous numerous ripple effects, improving outcomes, maintaining mobility and preserving dignity and independence for these individuals.
In an ambitious effort to further Yale University"s engagement in global health, President Richard C. Levin announced today the launch of the Yale Global Health Initiative. This is the first endeavor of the University"s new Jackson Institute of Global Affairs, which was announced in April. The purpose of the new initiative is to unite the many global health efforts across campus, foster innovative educational programs to address the growing student interest in global health, and stimulate and support faculty research to enhance healthcare around the world.
Men and women may not be from two different planets after all when it comes to choosiness in mate selection, according to new research from Northwestern University.
A promising antimicrobial agent already known to kill bacteria can also kill viruses and stimulate the innate immune system, according to researchers at National Jewish Health. In a paper appearing online June 4 in the Journal of Investigative Dermatology, Michael Howell, PhD, Assistant Professor of Pediatrics, and his colleagues demonstrated that the synthetic compound CSA-13 can kill vaccinia virus in cell cultures and in mice. Additionally, they showed that CSA-13 stimulates cells to produce their own antimicrobial proteins.
South Essex Partnership University NHS Foundation Trust (SEPT) is hosting an all day event for carers on Wednesday 10th June 2009. The event - You care We care - is taking place at the Towngate Theatre in Basildon and doors will open at 09:30.
The demand for more user-friendly healthcare IT professional services has been increasing across Europe. Companies that have delivered the right blend of 360 degree consulting, easier and shorter training sessions and exceptional operational services along with round-the-clock support and maintenance services have been displaying market leadership in terms of revenues and number of installed bases.
Australia"s regenerative medicine company, Mesoblast Limited (ASX:MSB)(PINK:MBLTY), announced positive three-month interim efficacy results from the first 20 patients enrolled in the Phase 2 heart failure trial of the proprietary allogeneic, or "off-the-shelf", adult stem cell product Revascor(TM).
Many hospitalized patients overestimate their chance of surviving an in-hospital cardiac arrest and do not know what CPR really involves, a University of Iowa study has shown.
Cancer develops when cells known as cancer stem cells begin to divide in
On Wednesday the BMA called on the Scottish Parliament Health Committee to support Government plans to remove the ability for commercial companies to provide NHS general practice services to patients.
Despite the efforts of college students to quit smoking, recent research conducted by Joyce M. Wolburg at Marquette University suggests that an extended trial and error period is necessary. Given that most college students begin smoking in high school, another study by faculty at HEC Montreal and University of Texas at San Antonio provides insights into how graphic cigarette warning labels impact intentions of American and Canadian teens. Both studies appear in the Summer 2009 issue of the Journal of Consumer Affairs.
A protein related to aggressive cancers can actually improve the efficacy of gemcitabine at treating pancreatic cancer, according to a Priority Report in Cancer Research, published by researchers at Thomas Jefferson University.
At the ends of chromosome are special pieces of DNA called telomeres. Think of it as the little tip that caps off a shoelace. The telomeres send signals to the cells to let them know it"s the end point, not a break that should be repaired.
The Royal Australian College of General Practitioners (RACGP) has released a new online learning activity designed to support general practitioners and other members of the general practice team in developing high quality care plans for people with intellectual disability, and in understanding eligibility requirements for Medicare-funded care plans.
Researchers at the University of California, San Diego School of Medicine have developed the first mouse model for auto-inflammatory diseases, disorders that involve the over-activation of the body"s innate, primitive immune system. Their study, published early on-line in Cell Immunity on June 4, suggests that the innate - not adaptive - immune system drives auto-inflammatory diseases. The findings could open new therapeutic directions for research into disorders such as gout or inflammatory bowel disease.
As the administration searches for ways to pay for health care reform and restrain medical costs, President Obama suggested Wednesday that he would consider transferring the power to set Medicare reimbursement rates from Congress to the independent advisory agency known as MedPAC, MedPage Today reports. The move reflects legislation introduced by Sen. Jay Rockefeller, D-W.Va., last month that would move MedPAC into the executive branch as "a regulatory board similar to the Federal Reserve ... The move would transfer the power to set reimbursement rates from Congress -- and perhaps the interest groups that lobby it -- to an agency that critics say is better equipped to make nuanced medical payment decisions" (Walker 3/09).