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NICE Recommends VIREAD (tenofovir Disoproxil Fumarate) For The Treatment Of Chronic Hepatitis B, UK
The National Institute for Health and Clinical Excellence

Discovery Links Proteins Necessary To Repair Membranes
Researchers at UMDNJ-Robert Wood Johnson Medical School are a step closer to treating, and perhaps preventing, muscle damage caused by disease and aging. In their study, published in the June issue of Journal of Biological Chemistry, the scientists have linked the newly discovered protein MG53 to a pathway that repairs human muscle tissue along with the proteins caveolin-3 (Cav3) and dysferlin. Prior to this study, the underlying interactions that inhibited membrane repair in muscle tissue were unknown. Linking these proteins creates a mechanism that allows damaged membranes to be repaired, which may transform treatment for patients who suffer from severe complications of diseases such as muscular dystrophy, as well as cardiovascular disorders and conditions related to advancing age.
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Sotomayor Nomination Raises Questions About How Female Judges View Cases Differently
Following President Obama"s nomination of Judge Sonia Sotomayor to replace retiring Supreme Court Justice David Souter, the differences between how male and female judges see and rule on cases has come into question, the New York Times reports. Although retired Supreme Court Justice Sandra Day O"Connor, the first woman to serve on the Supreme Court, often said that a female judge would come to the same decision as a male judge, Justice Ruth Bader Ginsburg has said that her perspective on certain cases is different because of her gender.The Times cites two examples, one involving the strip search of a 13-year-old girl -- to which Ginsburg said that her male colleagues could not understand how the girl felt. The second example involves the issue of certain abortion procedures. When deciding about the constitutionality of a federal ban on so-called "partial-birth" abortions, Ginsburg took issue with Justice Anthony Kennedy"s majority opinion that women who undergo the procedure likely would experience attacks of conscience. She responded that Kennedy"s views reflected "ancient notions of women"s place in the family and under the Constitution -- ideas that have long since been discredited."The issue has come up again with Sotomayor"s nomination, specifically regarding her 2001 statement that she "would hope that a wise Latina woman with the richness of her experiences would more often than not reach a better conclusion than a white male who hasn"t lived that life." The perception that female judges inherently might view cases differently than male judges has raised some concerns even among some female judges who believe it might be true, according to the Times. Judge Judith Kaye, former chief judge of New York state, said that she avoided discussing the issue with others but then accepted the idea that female judges see things differently at times. "To defend the idea that women come out different on some cases, I just feel it," Kaye said, adding, "I feel it to the depths of my soul" because women"s experiences are "just different." Attorney Lawrence Robbins, however, said, "Any person in the real world should be highly reluctant to make these broad generalizations."The most recent study comparing male and female judges found that female judges were more likely to rule in favor of plaintiffs who claim sex discrimination at workplaces. The study also found no differences in cases involving disability law, environmental issues and capital punishment (Lewis, New York Times, 6/3).
Mental Health

Successful Neurosurgery With Transcranial MR-guided High-Intensity Focused Ultrasound

The Magnetic Resonance Center of the University Children"s Hospital Zurich has achieved a world first break through in MR-guided, non-invasive neurosurgery. Ten patients have been successfully treated by means of transcranial high-intensity focused ultrasound. This fully non-invasive procedure opens new horizons for neurosurgery and the treatment of different neurological brain disorders. In the context of a clinical study at the MR Center of the University Children"s Hospital Zurich transcranial MR-guided high-intensity focused ultrasound (HIFU) for brain surgery has been successfully applied for the first time world-wide. A research team under the direction of Professor Daniel Jeanmonod, neurosurgeon at the Department of Functional Neurosurgery of the Neurosurgical Clinic at the University Hospital Zurich and Professor Ernst Martin, director of the Magnetic Resonance Center at the University Children"s Hospital Zurich succeeded in proving the safety and efficacy of this revolutionary surgical method which permits fully non-invasive brain interventions even on an out-patient basis. For quite some years, HIFU has been used for the treatment of uterine fibroids and tumors of the prostate gland. However, its application to the brain through the intact skull for non-invasive neurosurgery was not possible until recently, because of insurmountable technical difficulties. Non-invasive neurosurgery In a Swiss National research project, the team of the University of Zurich successfully implemented and optimized a prototype system for transcranial Magnetic Resonance-guided High-Intensity Focused Ultrasound (HIFU) for neurosurgical interventions. The HIFU system ExAblate® 4000, developed by the cooperation partner InSightec, Tirat Carmel Israel, has been combined with a 3 Tesla high field GE MR-scanner. The two systems together provide a platform for image-guided, non-invasive interventions. Since September 2008 ten patients were treated at the Children"s Hospital Zurich with this new neurosurgical procedure in the context of a clinical study. All interventions were completed successfully and without complications. This novel technology now opens up new horizons allowing to develop non-invasive intervention procedures for a variety of brain diseases including brain tumors. The whole surgical procedure is planned and monitored in real time by magnetic resonance imaging (MRI). The HIFU beams produced by 1024 transducers are transferred through the intact skull of the patient into the brain and concentrated onto a focus of 3 to 4 millimeters in diameter. Thus, sharply defined targets deep inside the brain are coagulated by heating them up to a focal temperature of 60 degrees Celsius. The temperature increase during the sequential ň€žsonications", each lasting 10 to 20 seconds, is continuously displayed and controlled on precise MR-temperature distribution maps. The whole surgical procedure lasts several hours and is performed without anaesthesia. Patients are awake and fully conscious during the intervention. A project of the National Centre of Competence in Research (NCCR) Co-Me In the context of the Swiss National Research Program NCCR Co-Me (computer aided and image guided medical interventions), the potential of non-invasive, transcranial MR-guided high-intensity focused ultrasound (tcMRgHIFU) is investigated in clinical studies at the University Children"s Hospital Zurich. Scientists working in the Co-Me program pursue the goal of establishing and developing surgical interventions by means of tcMRgHIFU, in order to broaden the spectrum of completely non-invasive interventions for functional neurosurgery and for the treatment of brain tumors, stroke and various neurological brain disorders by targeted drug delivery. The research project represents a co-operation between the University of Zurich and the ETH Zurich, through (A) the Magnetic Resonance Center of the University Children"s Hospital (Professor Ernst Martin), (B) the Department of Functional Neurosurgery of the Neurosurgical Clinic at the University Hospital Zurich (Professor Daniel Jeanmonod), (C) the Medical Image Analysis and Computer Vision Laboratory of the ETH Zurich (Professor Gabor SzÓ©kely) and (D) the Institute of Neuroinformatics, ETH Zurich (PD Dr. Daniel Kiper), as well as the industrial partner InSightec Ltd. Zurich University


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