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Mayo Clinic Proceedings: A Comprehensive Review Of Addiction To Prescription Painkillers Among Patients And Physicians
Chemical dependency and recovery in patients and physicians are closely examined in a series of articles and editorials in the July 2009 issue of Mayo Clinic Proceedings. The subject is especially timely. As the immense challenges, including potential tragedies, of prescription chemical addiction and abuse are being discussed, these articles offer crucial overview, direction and optimism.

Merseyside Nurse Jailed For 9 Months For Fraud
A nurse has been sentenced to 9 months" imprisonment at Liverpool Crown Court (15th June, 2009) for obtaining an NHS bursary and then employment in a private nursing home using forged documents, after overstaying his leave to remain in the UK. The conviction follows an investigation by NHS Counter Fraud.
News of the day
A Selection Of Recent Studies And Surveys
National Cancer Institute: Racial Disparities in Breast Cancer Mortality Are Not Driven by Estrogen Receptor Status Alone -- "Black women who are diagnosed with breast cancer have a higher probability of dying from the disease than white women, regardless of their estrogen receptor status," a study published online in the Journal of the National Cancer Institute finds, according to a NCI description of the document. By comparing the breast cancer rates for black and white women using data from the NCI"s Surveillance, Epidemiology and End Result (SEER) program, researchers found that the "differences in breast cancer mortality may reflect racial differences in access and response to innovative breast cancer treatments, as well as other biological and non-biological factors" and "differences in outcomes in the first few years post-diagnosis make up nearly all of the disparity" (7/7).
Diagnostics

Smoking Increases Potential For Metastatic Pancreatic Cancer

Smoking has once again been implicated in the development of advanced cancer. Exposure to nicotine by way of cigarette smoking may increase the likelihood that pancreatic ductal adenocarcinoma will become metastatic, according to researchers from the Kimmel Cancer Center at Jefferson. Their study was published in the August edition of the journal Surgery. The culprit behind the increased metastasis potential appears to be an isoform (variant type) of a protein called osteopontin, according to Hwyda Arafat, M.D. Ph.D., an associate professor of Surgery at Jefferson Medical College of Thomas Jefferson University and a member of the Jefferson Pancreatic, Biliary & Related Cancers Center. Nicotine promotes the expression osteopontin, and high levels of osteopontin have been reported in pancreatic ductal carcinoma (PDA). Dr. Arafat and her research team analyzed PDA samples and confirmed that the isoform, called OPNc, was also expressed on invasive PDA lesions. Previous studies have shown that OPNc is expressed in several invasive cancers, and supports metastatic behavior. The researchers correlated OPNc expression with the patients" smoking history. OPNc expression was found on 87 percent of the invasive PDA lesions analyzed, of which 73 percent were from smokers. The OPNc expression also correlated with higher expression levels of osteopontin. Premalignant lesions expressed no OPNc. "This is the first time a relationship between nicotine and OPNc expression has been identified," Dr. Arafat said. "These data are very exciting because now we can evaluate OPNc as a prognostic and diagnostic marker of invasive PDA lesions. "Because of the lower expression levels of OPNc in non-smokers, OPNc may be regulated by nicotine, which is another novel finding of this study. The exact role of OPNc in PDA remains to be defined, but it could provide a unique potential target to control pancreatic cancer aggressiveness, especially in people who smoke cigarettes." Pancreatic cancer is the fourth-leading cause of cancer death in the country, taking 34,000 lives a year. Only four percent of individuals with pancreatic cancer live for five years after diagnosis. Thomas Jefferson University


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