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Amgen Announces KRAS Safety Update To U.S. Prescribing Information For Vectibix(R) (Panitumumab)
Amgen Inc. (Nasdaq: AMGN) announced the U.S. Food and Drug Administration (FDA) has approved revisions to the U.S. prescribing information for the epidermal growth factor receptor (EGFr) class of antibodies, including Vectibix((R)) (panitumumab). This decision follows the FDA"s December 2008 Oncologics Drugs Advisory Committee (ODAC) meeting where the clinical utility of the KRAS gene as a predictive biomarker in patients with metastatic colorectal cancer (mCRC) treated with anti-EGFr antibody was discussed.

Demand For User-friendly Healthcare IT Professional Services Increasing Across Europe, States Frost & Sullivan
The demand for more user-friendly healthcare IT professional services has been increasing across Europe. Companies that have delivered the right blend of 360 degree consulting, easier and shorter training sessions and exceptional operational services along with round-the-clock support and maintenance services have been displaying market leadership in terms of revenues and number of installed bases.
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Demand For User-friendly Healthcare IT Professional Services Increasing Across Europe, States Frost & Sullivan
The demand for more user-friendly healthcare IT professional services has been increasing across Europe. Companies that have delivered the right blend of 360 degree consulting, easier and shorter training sessions and exceptional operational services along with round-the-clock support and maintenance services have been displaying market leadership in terms of revenues and number of installed bases.
Cardiovascular

Rates Of Severe Childhood Obesity Have Tripled

Rates of severe childhood obesity have tripled in the last 25 years, putting many children at risk for diabetes and heart disease, according to a report in Academic Pediatrics by an obesity expert at Brenner Children"s Hospital, part of Wake Forest University Baptist Medical Center. "Children are not only becoming obese, but becoming severely obese, which impacts their overall health," said Joseph Skelton, M.D., lead author and director of the Brenner FIT (Families in Training) Program. "These findings reinforce the fact that medically-based programs to treat obesity are needed throughout the United States and insurance companies should be encouraged to cover this care." The research was published on-line and will appear in the September print edition. Skelton and colleagues compared data from the National Health and Nutrition Examination Survey (NHANES). They looked at the prevalence of obesity and severe obesity in a study population of 12,384 children, representing approximately 71 million U.S. children ages 2 to 19 years. Severe childhood obesity is a new classification for children and describes those with a body mass index (BMI) that is equal to or greater than the 99th percentile for age and gender. For example, a 10-year-old child with a BMI of 24 would be considered severely obese, Skelton said, whereas in an adult, that is considered a normal BMI. An expert committee convened by the American Medical Association, the Centers for Disease Control and the Department of Health and Human Services proposed the new classification in 2007. The research by Skelton and colleagues is the first of its kind to use the new classification and detail the severity of the problem. They found that the prevalence of severe obesity tripled (from 0.8 percent to 3.8 percent) in the period from 1976-80 to 1999-2004. Based on the data, there are 2.7 million children in the U.S. who are considered severely obese. Increases in severe obesity were highest among blacks and Mexican-Americans and among those below the poverty level. For example, the percentage of Mexican-American children in the severely obese category was 0.9 percent in 1976-80 and 5.2 percent in 1999-2004. Researchers also looked at the impact of severe obesity and found that a third of children in the severely obese category were classified as having metabolic syndrome, a group of risk factors for heart attack, stroke and diabetes. These risk factors include higher-than normal blood pressure, cholesterol and insulin levels. "These findings demonstrate the significant health risks facing this morbidly obese group," wrote the researchers in their report. "This places demands on health care and community services, especially because the highest rates are among children who are frequently underserved by the health care system." The research was supported, in part, by the National Institutes of the Health and the Robert Wood Johnson Foundation. Co-researchers were: Stephen Cook, M.D., M.P.H.; Peggy Auinger, M.S.; Jonathan Klein, M.D., M.P.H.; University of Rochester School of Medicine and Dentistry; and Sarah Barlow, M.D., M.P.H., Baylor College of Medicine. Rae Bush Wake Forest University Baptist Medical Center


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