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Total Knee Replacement Appears Cost-Effective In Older Adults
Total knee replacement (arthroplasty) appears to be a cost-effective procedure for older adults with advanced osteoarthritis, according to a report in the June 22 issue of Archives of Internal Medicine, one of the JAMA/Archives journals. The procedure appears to be cost-effective across all patient risk groups, and appeared more costly and less effective in low-volume centers than in high-volume centers.

Moderates Wooed In House As They Cross Party Lines To Shape Health Legislation
As attempts to gain support for health reform across party lines and from stoic interest groups like the American Medical Association continue, House leaders are seeking to rally centrist members of their own caucus, CQ Politics reports. "House Speaker Nancy Pelosi, whose liberal committee leaders will write health care legislation is attempting to engage moderate Democrats whose votes she will need on the floor."
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Genetic Test Reduces Need For Second Surgery In Breast Cancer Treatment
A new rapid test can confirm quickly and accurately that breast cancer has most likely not spread into adjacent lymph nodes, offering reassurance to patients and reducing the need for a second operation.
Oncology

Positive Preclinical Data On 2 Product Candidates At ENDO 09 Presented By Versartis

Versartis, Inc., an emerging company developing novel biologics with enhanced properties for patients with metabolic diseases, presented data for its long-acting product candidates, VRS-317 (hGH-rPEG) for treatment of growth hormone deficiency and for VRS-826 (IL-1ra-rPEG) for treatment of type 1 and type 2 diabetes, at the Endocrine Society"s Annual Meeting in Washington, DC. Versartis, through a unique licensing agreement with Amunix, Inc., uses the Amunix proprietary recombinant PEGylation (rPEG) technology to extend the half-life of established biologics. The preclinical Versartis compounds have the potential for significantly less frequent dosing and fewer side effects than those products currently on the market or in development. "New half-life extension data presented for the first time confirmed our expectation that dosing can be extended from weekly to monthly for our product candidates," said Jeffrey L. Cleland, Ph.D., Founder and Chief Executive Officer of Versartis. "Our preclinical data show that VRS-317 demonstrated in vivo potency equal to daily hGH, and sustained plasma levels and pharmacodynamic responses in monkeys without toxicity. Potential benefits of VRS-317 include its stability at room temperature in a liquid formulation and the ability to dose monthly with a small gauge needle, thus increasing patient safety and convenience. VRS-317 may become "best in class" hGH therapy when our preclinical studies are confirmed in human clinical trials." "Treatment of auto-inflammation in diabetes with IL-1ra has been demonstrated to increase beta-cell responsiveness in human clinical trials," Dr. Cleland continued. "Our new approach with VRS-826 will provide a less frequently administered treatment that should have comparable safety to IL-1ra, which binds both IL-1b and IL-1a. The results from preclinical studies of VRS-317 and VRS-826 were presented in poster sessions." An Extended Half-Life Human Growth Hormone Construct for Weekly Administration hGH-rPEG Poster Board Number P1-720 Wednesday, June 10, 2009 1:30 - 3:30 pm A Long Half-Life Interleukin-1-Receptor Antagonist for the Treatment of Type 2 Diabetes Mellitus IL-1ra-rPEG Poster Board Number P1-466 Wednesday, June 10,2009 1:30 - 3:30 pm Debra Bannister Versartis, Inc.


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