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Interest Groups Crowd Airwaves, Pursue Lawmakers
"The increasingly heated fight over health-care legislation is saturating the summer airwaves, with groups on all sides of the debate pouring tens of millions of dollars into advertising campaigns designed to push the cause of reform forward, slow it down or stop it in its tracks," the Washington Post reports. So far, drug makers, labor groups, Democrats and Republicans - among others - have spent $52 million to finance the ad campaigns, a heady start that could lead to a "record-breaking legislative battle."

Senators Seek $100 Billion For Health Reform From Insurers
"Key senators say they want to force the health insurance industry to pay as much as $100 billion toward the 10-year cost of the health care overhaul sought by President Obama," CQ Politics reports. The fees would come on top of a variety of other potential provisions that will change the landscape of their industry, from the requirement that insurers cover people with pre-existing conditions to a government-run plan meant to compete with insurers. The fee may appear in a Finance Committee version of the reform plan that hasn"t been released yet. That committee is responsible for finding ways to pay for the overhaul.
News of the day
Alexion's Soliris(R) Receives 2009 Prix Galien France For Most Innovative Drug For Rare Disease
Alexion Pharma France and Alexion Pharmaceuticals, Inc. (NASDAQ: ALXN) today received the 2009 Prix Galien France for Soliris® (eculizumab) in the category of medicines for rare diseases. The award recognizes the scientific innovation represented by the complement-inhibition technology of Soliris, and the impact the drug is having on the lives of patients with paroxysmal nocturnal hemoglobinuria (PNH), an ultra-rare, debilitating and life-threatening blood disorder.
Medical Devices

New Johns Hopkins Study Betters The Odds Of Success In Predicting The Return Of Prostate Cancer

Cancer experts at Johns Hopkins say a study tracking 774 prostate cancer patients for a median of eight years has shown that a three-way combination of measurements has the best chance yet of predicting disease metastasis. The new prediction method comprises the length of time it takes for PSA (prostate-specific antigen) to double, Gleason score (a numeric indicator of prostate cancer aggressiveness as seen under the microscope), and the interval between surgical removal of the prostate and the first detectable PSA level. According to Johns Hopkins investigators, combining these three measurements more accurately estimates risk that the cancer has spread than do other methods and should help determine which patients may benefit from additional therapy when PSA levels rise after surgery to remove the prostate. Findings from the study presented at the June 2009 annual meeting of the American Society of Clinical Oncology (ASCO) may also help resolve the debate on when and in what form secondary treatments should occur. "There is much debate on whether to prescribe immediate treatment for a man whose PSA begins to rise after he has had prostate cancer surgery, or to delay it," says Emmanuel Antonarakis, M.D., Johns Hopkins Kimmel Cancer Center investigator. "Studies suggest that most men live the same length of time overall whether they receive therapy at the first sign of a rising PSA or wait until the cancer has spread to other sites." After reviewing the records of 774 men whose PSA rose after surgery to remove the prostate, the researchers found that Gleason score and two measurements for PSA were the strongest risk factors for prostate cancer metastasis. Men with Gleason scores in the highest range, between eight and 10, were twice as likely to develop metastatic cancer. In men whose PSA became detectable within three years after surgery, cancer was more than three times more likely to spread to other organs. Finally, men whose PSA doubled the fastest, within three months, were more than 20 times more likely to develop metastatic cancer than men whose PSA look longer than 15 months to double. For men enrolled in the study, it took a median of 10 years for the disease to reappear on imaging scans. "The 10-year average will not apply to every man, so we wanted to know what factors put men at higher risk for their cancer progressing earlier," says Mario Eisenberger, M.D., professor of oncology at the Johns Hopkins Kimmel Cancer Center. An increase in PSA, or prostate specific antigen, occurs in approximately 20 percent to 30 percent of men after surgery to remove the cancerous prostate, says Antonarakis. In these patients, the newly emerging prostate cancer cells are rarely detectable on imaging scans. When faced with the likelihood that their cancer has spread, many men opt to undergo hormone therapy, which blocks testosterone production, a fuel for prostate cancer. The side effects, which mimic those of menopausal women, include hot flashes, night sweats, osteoporosis, metabolic syndrome and coronary disease, and can be debilitating, says Antonarakis. Besides immediate hormone therapy, other options for men whose PSA is rising are to use hormone therapy intermittently, enroll in clinical trials testing experimental therapies or combinations of them, or to "watch and wait" until imaging scans can locate metastatic disease. Notes: Data on the prostate cancer patients involved in this study were collected from a database maintained by Patrick C. Walsh, M.D., at the Johns Hopkins Brady Urological Institute. The information spans nearly 20 years of patient records at Johns Hopkins. The research was funded by the National Cancer Institute, the Prostate Cancer Foundation, and the Department of Defense Prostate Cancer Research Program. In addition to Antonarakis and Eisenberger, the following researchers participated in the study: Bruce Trock, Zhaoyong Feng, Elizabeth Humphreys, Michael Carducci, Alan Partin, and Patrick Walsh from Johns Hopkins. Amy Mone Johns Hopkins Medical Institutions


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