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Link Between Gene And Increasingly Common Type Of Blood Cancer
California and Arizona researchers have identified a gene variant that carries nearly twice the risk of developing an increasingly common type of blood cancer, according to a study published online by the science journal Nature Genetics.

From Oxygen Transport To Melanin Formation: Activation Mechanism Of Key Enzymes Explained
Pandinus imperator, the emperor scorpion, is not only popular as a pet, but is also of interest for research purposes. The reason for this is its blue blood, which transports oxygen and distributes it throughout the body. Like tyrosinase, the key enzyme in melanin synthesis, the blue blood pigment hemocyanin found in the emperor scorpion and other arthropods belongs to a group of special molecules that occur in all organisms and that have many different functions: coloring the skin, hair and eyes, immune response, wound healing or the brown discoloration of fruit. "When these enzymes mutate, this may result in albinism, or in birth marks when production of the pigment melanin increases, as often seen in melanoma," explains Professor Heinz Decker of Johannes Gutenberg University Mainz. The biophysicist has been studying hemocyanins and the associated tyrosinases for the past 20 years. In cooperation with researchers, Dr. Cong and Dr. Chiu, from the Baylor College of Medicine in Houston he has now been able to show for the first time exactly how the enzymes become active, thereby fulfilling their various functions. This work was published in the journal Structure on 13 May.
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Improvements In Diagnosis And Treatment Linked To Reduced Risk Of Death In Patients With Brain Haemorrhage
Improvements in diagnosis and treatment over the past 30 years have led to a 17% decrease in the likelihood of death from aneurysmal subarachnoid haemorrhage (the bursting of a blood vessel on the surface the brain) in the general population, according to an Article published Online First and in the July edition of The Lancet Neurology.
Diagnostics

Gendux Molecular Limited Withdraws Its Marketing Authorisation Application For Contusugene Ladenovec Gendux (contusugene Ladenovec)

The European Medicines Agency has been formally notified by Gendux Molecular Limited of its decision to withdraw its application for a centralised marketing authorisation for the medicine Contususgene ladenovec Gendux (contusugene ladenovec), suspension for injection. Contusugene ladenovec Gendux was expected to be used for the treatment of squamous cell carcinoma in head and neck cancer. The application for the marketing authorisation for Contususgene ladenovec Gendux was submitted to the Agency on 2 July 2008. At the time of withdrawal, it was under review by the Agency"s Committee for Medicinal Products for Human Use (CHMP). In its official letter, the company stated that the withdrawal of the application was based on the difficult financial situation of its parent company Introgen Therapeutics, Inc., which prohibits them to fund further activities related to this application. More information about Contusugene ladenovec Gendux and the state of the scientific assessment at the time of withdrawal will be made available in a question-and-answer document. This document, together with the withdrawal letter from the company, will be published on the Agency"s website shortly. European Medicines Agency


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