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Amgen Announces KRAS Safety Update To U.S. Prescribing Information For Vectibix(R) (Panitumumab)
Amgen Inc. (Nasdaq: AMGN) announced the U.S. Food and Drug Administration (FDA) has approved revisions to the U.S. prescribing information for the epidermal growth factor receptor (EGFr) class of antibodies, including Vectibix((R)) (panitumumab). This decision follows the FDA"s December 2008 Oncologics Drugs Advisory Committee (ODAC) meeting where the clinical utility of the KRAS gene as a predictive biomarker in patients with metastatic colorectal cancer (mCRC) treated with anti-EGFr antibody was discussed.

Comprehensive Look At Rare Leukemia Finds Relatively Few Genetic Changes Launch Disease
The most comprehensive analysis yet of the genome of childhood acute myeloid leukemia (AML) found only a few mistakes in the genetic blueprint, suggesting the cancer arises from just a handful of missteps, according to new findings from St. Jude Children"s Research Hospital. The research appears in the July 27 online edition of the Proceedings of the National Academy of Sciences.
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Analysis Of Edoxaban Phase II Data Provides Insight Into Reduced Bleeding Events Seen In Once-Daily Dosing
A sub-analysis of a Phase IIb multinational study(1) with edoxaban(2) - an investigational oral Factor Xa inhibitor - provides insights into why patients with non-valvular atrial fibrillation (AF) receiving edoxaban once daily (QD) experienced fewer bleeding events than patients given edoxaban twice a day (BID). The analysis finds that bleeding associated with edoxaban is most closely correlated with minimum concentration levels of the drug in the blood, and that these trough levels may best predict bleeding events, rather than total exposure or maximum concentration levels.
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Drummers Will 'Stick It To MS'

Over 600 drummers will gather in Birmingham"s National Indoor Arena on Monday 13 July to beat a world record in aid of the MS Society. The drumming challenge, which has been officially recognised by the Guinness Book of Records as a legitimate world record, requires over 533 drummers (the current record) to gather in one place with their drum kit and drum to the same beat. This is the first time the event has been attempted in the UK and famous faces from the world of music and entertainment are set to attend, including the soap actor, comedian and amateur drummer, John Thompson. Stick it to MS hopes to raise money for the MS Society through sponsorship, entry fees and spectator tickets. The charity has already received around ÷£20,000 from fundraisers taking part. Richard Prince, the event organiser, decided to run the event in aid of the MS Society in support of his mother, who has multiple sclerosis. Community fundraising manager, Hannah Chroston, said: "This is a great innovative and exciting event! We"re looking forward to seeing over 600 people "Stick it to MS" and want to thank Richard for all his hard work." For more information on the event view the Stick it to MS website. MS Society


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