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Zavesca(R) (miglustat) First Treatment Available In UK And Ireland For Rare Progressive Niemann-Pick Type C Disease
Actelion Ltd (SIX: ATLN) announced the launch of Zavesca® (miglustat) in the UK and Republic of Ireland; the first and only licensed treatment available for people with Niemann-Pick type C (NP-C) disease [1]. NP-C is a rare, genetic disease with significant neurological deterioration that can be fatal and affects infants, children and adults [2,3].

Every Daytime Sedentary Hour Adds Three Minutes To Time Children Take To Fall Asleep
Every hour of the day children are inactive adds three minutes to the time it takes them to fall asleep, finds research published ahead of print in Archives of Disease in Childhood.
News of the day
GAO Report Finds Veterans Affairs Facilities Do Not Comply With Privacy Standards For Women
All Department of Veterans Affairs outpatient clinics and hospitals are failing to fully comply with federal privacy standards for women, according to a Government Accountability Office report, the AP/Boston Globe reports. The report comes as thousands of female veterans are entering the VA health system after returning from Iraq and Afghanistan.GAO auditors said that many VA facilities had gynecological tables that faced the door. In one instance, a gynecological table faced a door opening to a waiting room. The investigation also found cases where women had to walk through waiting rooms to use the restroom -- a violation of VA policy requiring adjoining restrooms. Four VA hospitals did not guarantee women access to private bathing facilities. In two of those cases, the facilities did not have locks.Nearly 20% of female veterans have been diagnosed with post-traumatic stress disorder, and many of them have experienced sexual trauma while serving, according to the report. The report also said that most female veterans at VA facilities are ages 20 to 29. On average, female veterans using VA facilities are much younger than male VA patients, it noted.Randall Williamson, director of health care issues at GAO, said that although top VA officials are committed to improving care for female veterans, facilities are not always taking simple steps, such as repositioning exam tables. Patricia Hayes, chief consultant for VA"s veterans strategic health care group, said that the agency recognizes issues and is making changes to address disparities in care. She noted that VA is creating a long-term plan for construction improvements to address space and building layout challenges (AP/Boston Globe, 7/15).
Diagnostics

Darkness Linked To 'Brain Drain' In Depressed People

A lack of sunlight is associated with reduced cognitive function among depressed people. Researchers writing in BioMed Central"s open access journal Environmental Health used weather data from NASA satellites to measure sunlight exposure across the United States and linked this information to the prevalence of cognitive impairment in depressed people. Shia Kent, from the University of Alabama at Birmingham, led a team of US researchers who used cross-sectional data from 14,474 people in the NIH-NINDS-funded REGARDS study, a longitudinal study investigating stroke incidence and risk factors, to study associations between depression, cognitive function and sunlight. He said, "We found that among participants with depression, low exposure to sunlight was associated with a significantly higher predicted probability of cognitive impairment. This relationship remained significant after adjustment for season. This new finding that weather may not only affect mood, but also cognition, has significant implications for the treatment of depression, particularly seasonal affective disorder". Kent and his colleagues speculate that the physiological mechanisms that give rise to seasonal depression may also be involved in sunlight"s effect on cognitive function in the context of depressive symptoms. Cognitive function was assessed by measurement of short-term recall and temporal orientation. As well as regulating the hormones serotonin and melatonin, light has been shown to also affect brain blood flow, which has in turn been linked with cognitive functions. The researchers write, "Discovering the environment"s impact on cognitive functioning within the context of seasonal disorders may lead not only to better understanding of the disorders, but also to the development of targeted interventions to enhance everyday functioning and quality of life". Notes: Effect of sunlight exposure on cognitive function among depressed and non-depressed participants: a REGARDS cross-sectional study Shia T Kent, Leslie A McClure, William L Crosson, Donna K Arnett, Virginia G Wadley and Nalini Sathiakumar Environmental Health (in press) http://www.ehjournal.net/ Graeme Baldwin BioMed Central


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