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Darkness Linked To 'Brain Drain' In Depressed People
A lack of sunlight is associated with reduced cognitive function among depressed people. Researchers writing in BioMed Central"s open access journal Environmental Health used weather data from NASA satellites to measure sunlight exposure across the United States and linked this information to the prevalence of cognitive impairment in depressed people.
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Beating The Radar: Getting A Jump On Storm Prediction
Satellite observation of cloud temperatures may be able to accurately predict severe thunderstorms up to 45 minutes earlier than relying on traditional radar alone, say researchers at the University of Wisconsin-Madison Space Science and Engineering Center.
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Blogs Comment On Ryan-DeLauro Bill, Sex Education Funding, State Reproductive Health Legislation
The following summarizes selected women"s health-related blog entries.~ "A Taxing Problem," Jessica Arons, Huffington Post blogs: The five Democrats who last week sent a letter to House Speaker Nancy Pelosi (D-Calif.) "suggesting a "common ground" solution to the abortion "roadblock" in health care reform" should be "applauded" for keeping the debate"s focus on covering the uninsured and "for being unwilling to sacrifice health care reform on the altar of abortion politics," writes Jessica Arons, director of the Women"s Health & Rights Program at the Center for American Progress. Arons adds that while the proposal, led by antiabortion-rights Rep. Tim Ryan (D-Ohio), "is in welcome contrast to the stonewalling and ultimatums coming from Rep. Bart Stupak (D-Mich.) and his allies," it is "based on a misguided and attenuated definition of government spending, and it conflicts with what Americans want and expect from health care reform." She continues that the "suggestion that a health plan might offer abortion coverage, and it might be used by someone, who might have paid a lower premium than someone else, because the government might have helped pay their premium is a horrible reason for Congress to carve out an explicit exception to a bill that is otherwise entirely silent on coverage options." Taxpayers "do not have the right to specify how their tax money should be spent," she writes, adding, "I understand why people would want to withhold their taxes from purposes they oppose, but our system does not -- nor should it -- work that way" (Arons, Huffington Post blogs, 7/30).~ "The Breakup of the Pro-Life Movement," Cristina Page, Birth Control Watch: Rep. Ryan is "in many ways a typical pro-life American" who opposes abortion rights and, "like most pro-life Americans, ... supports every effort to prevent the need for it," including contraception, Page writes. However, because of his support for contraception and sponsorship of the "Preventing Unintended Pregnancies, Reducing the Need for Abortion and Supporting Parents Act," Ryan was "banished" from the board of Democrats for Life of America, Page writes, adding that antiabortion-rights publications have "taken to qualifying his pro-life status as "allegedly" pro-life or referring to him as someone "who claims to be" pro-life." The bill, also known as the Ryan-DeLauro bill, would increase funding for contraception, and support comprehensive sex education and services for women who choose to carry unintended pregnancies to term, Page writes. She notes that the bill is supported by "many prominent pro-life individuals" and groups that support abortion rights, though "[n]ot one leading pro-life group signed onto the bill." Page writes, "Pro-life Americans favor expanding access to contraception because of the undeniable pro-life results," adding, "Unintended pregnancy is the root cause of abortion. We know when used properly, contraception works." It is "time for the disagreement over contraception to be addressed by the pro-life community at large," she writes, adding, "We will have no chance of making a real impact on unintended pregnancy and abortion rates without dramatic, informed strategies on prevention" (Page, Birth Control Watch, 7/28).~ "Senate Subcommittee: Ab-Only Out, Syringe Ban Still In; Advocates Hope for Further Changes in Conference Committee," Jodi Jacobson, RH Reality Check: The spending bill approved yesterday by the Senate Appropriations Committee "zeroes out funding" for the Community-Based Abstinence Education program, which has "for years [been] the main of support for now-discredited abstinence-only programs," Jacobson writes. The "elimination of these funds parallels similar action in the House, ... so unless amendments are proposed, accepted and passed during either the full committee vote or on the Senate floor, this bill spells "the end of abstinence-only programs as we know them," said one advocate, "at least for this year,"" Jacobson writes. The Senate version of the bill allocate
Medical Devices

Controversial Cancer Stem Cells Offer New Direction For Treatment

In a review in Science, a University of Rochester Medical Center researcher sorts out the controversy and promise around a dangerous subtype of cancer cells, known as cancer stem cells, which seem capable of resisting many modern treatments. The article proposes that this subpopulation of malignant cells may one day provide an important avenue for controlling cancer, especially if new treatments that target the cancer stem cell are developed and combined with traditional chemotherapy and/or radiation. "The fact that these concepts are steadily making their way into the clinic is exciting, and suggests that the recent interest in cancer stem cells may yield beneficial outcomes in potentially unexpected ways," wrote co-authors Craig T. Jordan, Ph.D., professor of Medicine at URMC and director of the James P. Wilmot Cancer Center Translational Research for Hematologic Malignancies program; and Jeffrey Rosen, Ph.D., the C.C. Bell Professor of Molecular and Cellular Biology and Medicine at Baylor College of Medicine. Cancer stem cells (CSCs) are a hot topic in the scientific community. First identified in 1994 in relation to acute myeloid leukemia, CSCs have now been identified in several solid tumors in mice as well. Scientists who study CSCs believe they have distinct properties from other cancer cells, and may be the first cells to undergo mutations. Research from the past 10 years suggests that because CSCs may be the root of cancer, they also might provide a new opportunity for a treatment. Jordan and a group of collaborators, for example, are testing a new drug compound based on the feverfew plant that demonstrates great potential in the laboratory for causing leukemia CSCs to self destruct. Another new approach, the authors said, is the use of chemical screens to search drug libraries for already approved agents that may target CSCs, or make resistant tumor cells more sensitive to chemotherapy and radiation. Cancer stem cell biologists hypothesize that any treatment that targets the of origin rather than simply killing all cells, healthy and malignant, would be an improvement over most conventional therapies. Some scientists, however, are uncertain if CSCs have unique biological properties or any relevance to treatment, the authors noted. What is more likely to fuel cancer, other studies have found, are unfavorable factors in the neighboring cells surrounding the tumor, such as mutated genes, proteins that encourage cell growth, and a poor immune system, for instance. The most challenging issue facing CSC biologists is that the number and type of cancer stem cells can vary from patient to patient. In some tumor samples, for example, CSCs are rare while in others they constitute a large portion of the tumor mass, the authors said. To understand why CSCs are so variable, investigators are trying to determine what genes and pathways are responsible for activating cancers that have a poor prognosis, and whether these cancers also have a higher frequency of CSCs. "Whether the cancer stem cell model is relevant to all cancers or not," they wrote, "it is clear that we need new approaches to target tumor cells that are resistant to current therapies and give rise to recurrence and treatment failure." An unexpected benefit of so much attention on normal stem cells is that it has stimulated research in areas not previously the focus of cancer therapies, Jordan and Rosen said. For example, pathways known to be important for normal stem cell self-renewal, such as the Wnt, Notch and Hedgehog(Hh) pathways, are now of increased interest due to their potential role in CSCs. The first clinical trial using an agent to block the Notch pathway in combination with chemotherapy for breast cancer has begun. The authors conclude by spotlighting the pressing need for preclinical models to test appropriate doses and combinations of CSC therapies before they can move into human clinical trials. Leslie Orr University of Rochester Medical Center


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