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Comprehensive Look At Rare Leukemia Finds Relatively Few Genetic Changes Launch Disease
The most comprehensive analysis yet of the genome of childhood acute myeloid leukemia (AML) found only a few mistakes in the genetic blueprint, suggesting the cancer arises from just a handful of missteps, according to new findings from St. Jude Children"s Research Hospital. The research appears in the July 27 online edition of the Proceedings of the National Academy of Sciences.
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U.S. Marshals Seize Drug Products Manufactured By Caraco Pharmaceutical Laboratories Ltd. FDA Acts To Prevent Repeated Drug Quality Problems
U.S. Marshals, at the request of the Food and Drug Administration, today seized drug products manufactured by Caraco Pharmaceutical Laboratories Ltd. (Caraco), at the company"s Michigan facilities in Detroit, Farmington Hills, and Wixom. The seizure also includes ingredients held at these same facilities. "The FDA is committed to taking enforcement action against firms that do not manufacture drugs in accordance with our good manufacturing practice requirements," said Janet Woodcock, M.D., director of the FDA"s Center for Drug Evaluation and Research. "Compliance with these standards prevents harm to the public."
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The Necessity Of Adrenalectomy At The Time Of Radical Nephrectomy: A Systematic Review
UroToday.com - We undertook a systematic review of the literature in reference to the use of ipsilateral adrenalectomy at the time of radical nephrectomy for the treatment of renal cell carcinoma. Important in the understanding of this is accurately defining..
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Blankets Instead Of Drugs To Avoid The Shivers In Brain Damage

Have you ever covered yourself with a blanket to stave off the shivers? A new study shows that a blanket can also help alleviate shivering in patients who have been cooled to prevent brain damage. Patients with brain injuries or dangerously high fevers are often cooled to reduce their core body temperature to prevent further damage and aid healing. Unfortunately, cooling induces a natural and familiar response - shivering. This shivering counteracts efforts to keep the patient"s temperature low, causes physical stress, and is currently treated with sedatives and other drugs. Now, a study recommended by Andreas Kramer, a member of Faculty of 1000 Medicine and leading expert in the field of critical care medicine, demonstrates that simply warming the skin can decrease shivering in many patients, without the need for drugs. Physicians at Columbia University and the New York Presbyterian Hospital found that the intensity of shivering and physiological stress increased when warming blankets were removed from therapeutically cooled patients. Shivering subsided when the blankets were replaced. Though warming the skin does not reduce shivering in all patients, Kramer concludes that "its simplicity, low cost, widespread availability, lack of adverse effects, and the potential to avoid sedation ... make it an attractive treatment option." Andreas Kramer, Faculty Member for F1000 Medicine, is Clinical Assistant Professor in the Departments of Critical Care Medicine and Clinical Neuroscience at University of Calgary, Canada. Kathleen Wets Faculty of 1000: Biology and Medicine


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