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National HIV/AIDS Advocate, Physician Joel Weisman Dies In California
Joel Weisman, "one of the first physicians to detect the AIDS epidemic and who became a national advocate for AIDS research, treatment and prevention," died on Saturday at his home in Westwood, Calif., the Los Angeles Times reports. Weisman was 66. Weisman was a general practitioner in southern California when in 1980 he first saw three ill gay men with a set of mysterious symptoms. He later contributed to the June 5, 1981 CDC Morbidity and Mortality Weekly Report, which "signaled the official start of the epidemic that the federal agency later named acquired immunodeficiency syndrome," according to the Times. Weisman was the founding chair of AIDS Project Los Angeles in 1983, helped organize the first dedicated hospital AIDS unit in Southern California and was an original board member of amfAR, the Foundation for AIDS Research (Woo, 7/23).

Emphasis On Self-Awareness And Personal Will In Groundbreaking 'Reorganizational Healing' Model
Reorganizational Healing (ROH), an emerging concept for wellness, healing, and personal growth, is explored in depth in a seminal groundbreaking article and accompanying commentaries in the latest issue of The Journal of Alternative and Complementary Medicine, a peer-reviewed journal published by Mary Ann Liebert, Inc. The Reorganizational Healing articles are available free online at http://www.liebertpub.com/acm.
News of the day
Celera Presents Data Replicating Its Immunodiagnostic Assay To Detect Lung Cancer From Blood Serum
Celera Corporation (NASDAQ:CRA) announced yesterday the presentation of data replicating its novel mass spectrometry-based approach to identify and validate circulating protein biomarkers that detect non-small cell lung cancer (NSCLC) in an independent cohort of individuals with lung cancer. This study was performed in collaboration with scientists at NYU Langone Medical Center, NY. A key outcome of the study was the validation of a 9 biomarker immunoassay on a cohort of samples that is enriched for stage I disease, important for screening of early stage disease. The assay detected lung cancer with 92% sensitivity at 93% specificity. The panel also accurately distinguished malignant cases from benign lung disease. The data is being presented at the 13th World Conference on Lung Cancer as part of the International Association for the Study of Lung Cancer (IASLC) in San Francisco, CA.
Oncology

A Breakthrough In Gastric Carcinogenesis

Checkpoint with forkhead and ring finger (CHFR) is a mitotic stress checkpoint gene whose promoter is frequently methylated in various kinds of cancer. In gastric cancer, CHFR promoter hypermethylation has been reported to lead to chromosome instability (CIN) and genetic instability is one of the hallmarks of human cancer. A research team led by Dr Eiji Oki from Kyushu University examined the methylation status of the promoter region of CHFR and microsatellite instability (MIN) status in primary gastric cancers. Their study was published on May 28, 2009 in the World Journal of Gastroenterology. They investigated the promoter methylation of CHFR in 59 cases of gastric cancer using methylation-specific PCR. Five microsatellite loci were analyzed using high-intensity microsatellite analysis reported previously, and p53 gene mutations were investigated by direct sequencing. They found that twenty cases (33.9%) showed promoter methylation and no relation was observed with the clinicopathological factors. The promoter methylation of CHFR was frequently accompanied with MIN. Seven of 20 (35.0%) cases showed MIN in hypermethylation of the CHFR tumor, while three of 39 (7.7%) cases showed MIN in the non-methylated CHFR tumor (P World J Gastroenterol 2009; 15(20): 2520-2525. Correspondence to: Eiji Oki, MD, PhD, Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Lai-Fu Li World Journal of Gastroenterology


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